Dedicated equipment and experienced scientists are available to select the best solution to suite your goals.

Imaging is a non-invasive technique that allows repeated measurements of disease progression or recovery in the same subject, which exactly mimics the clinical condition, thus saving animals, time and money. Impressive resolution of anatomical details are obtained even in smallest animals, and functional imaging gives important information on metabolism.

The recent development of genetically-modified animals opens the opportunity to visualize in real time almost any physiological and pathological process in small animals, with substantial boosting of the screening efficacy as well as the understanding of the mechanism(s) of action. The cost-effectiveness of this approach is particularly advantageous during the screening for efficacy.

Magnetic resonance, Nuclear medicine and X-Ray, Ultrasound Imaging and Optical Imaging facilities are available to provide studies for the evaluation of drug candidates in different areas such as oncology, cardiovascular, cerebral, inflammation, drug-absorption and gene expression.

Heterozygous (NJ) and homozygous recessive jaundiced (JJ) Gunn rats (14-16 days old) were investigated in vivo by MRI before and after of the acute increase of unconjugated or indirect bilirubin in brain tissues. Imaging at 3,T2 weighted images.

 

 

In vivo Time-Domain Optical Imaging: Ab-Cy5.5 Intraperitoneal Injection

 

 

RI-Cy5.5 injected into lymphoma-bearing mice revealed a slow tumor uptake and a specific long-lasting persistence of the probe within the tumor. RI-Cy5.5 selectively accumulated in the tumor tissue and major excretion organs. In summary, the study indicates that NIR TD optical imaging is a powerful tool for rituximab-targeting investigation, furthering understanding of its administration outcome in lymphoma treatment.

 

 

Mice can be genetically modified by inserting a stable luciferase gene to result in an easy-to-detect light signal in response to tissue specific activity. This enables monitoring physiology, pathology, drug or nutraceutical actions, toxic effects in the intact living organism.

Skin Wound Healing assay inexpensive, direct and accurate in vivo quantification of proliferation in wound healing.

 

In the repTOPTM mitoIRE mice, proliferation in the wound area can be visualized and measured in vivo simply by taking a picture of the anaesthetized mouse with a CCD camera. The extent of the regenerative effect of the treatment is directly proportional to the photon emission measured.