The complete range of in-vivo and in-vitro studies are offered to enable the characterization of the absorption, distribution metabolism and excretion (ADME) and Drug Metabolism and Pharmacokinetics (DMPK) of candidate pharmaceuticals and bio-pharmaceuticals.

The in vivo studies are performed using the animal species used in toxicology using the administration routes relevant to the therapeutic use of the drug.


  • ¬†Absorption and bio-availability
  • Quantitative tissue distribution
  • Metabolite identification (LC-MS/MS & NMR)
  • Biliary excretion and enterohepatic circulation
  • Excretion/Balance
  • Pharmacokinetics and statistical data analysis
  • Placental transfer
  • Milk excretion



In vitro studies:

  • Protein binding
  • Metabolic profiles
  • Metabolic stability-P450 isoform identification
  • P450 inhibition potential
  • Enzyme induction
  • Drug/drug interaction studies
  • Dermal penetration

Species comparison of metabolic profiles