In vitro Cultures of osteoblasts, osteoclasts, synoviocytes and chondrocytes (bi- and tri-dimensional models) to mimic the disease and assess drug functionality by measuring: Cytokine Release Collagen Synthesis Hyaluronic Acid Synthesis GAG Synthesis Enzyme Activities Bone Mineralization Bone Resorption/Formation Phenotype Gene Expression (PCR, Qpcr, Microarrays) Proteome Analysis Models to study drug stability/solubility in synovial fluid (simulated or fresh, from healthy and…

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Dedicated equipment and experienced scientists are available to select the best solution to suite your goals. Imaging is a non-invasive technique that allows repeated measurements of disease progression or recovery in the same subject, which exactly mimics the clinical condition, thus saving animals, time and money. Impressive resolution of anatomical details are obtained even in…

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