General Pharmacology More than 100 classical pharmacology validated assays are available for the evaluation of the pharmacological activity of candidate drugs. Isolated Organs Isolated ileum Guinea pig Isolated duodenum Isolated trachea Isolated uterus Isolated vas deferens Isolated urethra Isolated trigone Isolated corpus cavernosum Isolated colon Isolated bladder Renal Function Saline overload diuresis Streptozotocin induced renal…

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Core Battery  Central Nervous System : Motor activity, behavioral changes, coordination, sensory/motor reflex responses and body temperature functional observation battery (FOB) , modified Irwin’s test Cardiovascular System : Blood pressure, heart rate, electrocardiogram, QT interval in telemetered animals. In vitro QT interval prolongation ( hERG ) Respiratory System: Respiratory rate and other measures of respiratory…

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